Endocannabinoid Deficiency

What is Endocannabinoid Deficiency?

The influx in cannabinoid research has uncovered some very interesting results. It is now widely accepted that chemicals found in Hemp derived CBD products have the ability to influence Homeostasis in our bodies. They have the ability to both reduce overactive responses and increase productive responses in all the major systems in our body ultimately acting as biological regulators.

Cannabinoids achieve these effects in part by acting upon the Endocannabinoid System ( ECS ) a system comprised of enzymes, signalling lipids, and G-protein coupled receptors known as the CB1 and CB2 receptors

A 2008 paper published within the journal Endocrine, Metabolic & Immune Disorders Drug Targets explains the important role of the ECS in homeostasis, stating its involvement in neuroprotection and neural plasticity, immunity and inflammation, apoptosis and carcinogenesis, pain and emotional memory, and hunger, feeding, and metabolism.


A 2016 paper published within the journal Cell states that changes in human ecology such as diet, physical activity, population density, and microbial exposure have dramatically changed the types of human diseases of the last century. These modern diseases involve two main features: disruption of homeostasis and chronic inflammation.
Homeostatic systems can have a fixed point or multiple adjustable set points. Homeostatic diseases can arise when a system becomes stuck in an alternative stable state. Some diseases that stem from homeostatic disruption include dyslipidemia, diabetes, obesity, high blood pressure, arthritis, osteoporosis, thyroid disorders, and endocrine disorders.

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